The market for hair health supplements is growing rapidly. Transparency Market Research estimates a global CAGR of 11.5% for this category between 2021 and 2031.1 This growth is driven in part by emerging consumer concerns about hair loss after COVID-19 infection, but also by factors such as dietary gaps and growing consumer understanding of the importance of nutrition to hair health. Factors have largely contributed to the resurgence of interest in hair health products.
Consumers are now looking for research-validated ingredients and formulas that address multiple aspects of hair health, and companies and ingredient developers are responding. I will continue.
Aging hair meets beauty from the inside
Consumers are now learning more about hair health nutrition and supplement companies are presenting new ingredients to appeal to consumers.Co-founder of hair supplement brand Nutrafol (New York City) , chief innovation and product officer Roland Peralta, said as consumers become more knowledgeable about hair health, formulas will become more sophisticated to address multiple nutritional gaps. For example, he says he now has a better grasp of the relationship between hair health, stress and nutrition.
And “personalization is trending with new formulations,” adds Peralta. “We are in an era where at-home tests and wearable devices allow us to learn real-time data about ourselves. , guides our lifestyle choices and product choices.
Nutrafol’s core product line consists of four nutraceutical blends designed to improve hair growth and combat thinning hair. Each product is formulated for a different audience using the company’s patented Synergen Complex, which incorporates different ingredients for men, premenopausal women, postmenopausal women, and new mothers. increase.
This February, Nutrafol made a big splash with a new product called Collagen Infusion, a collagen-based powder mixture that can be added to hot or cold liquids, including foods like yogurt, soups, and smoothies. The drink mix can be used in combination with the company’s other aforementioned foundational hair growth supplement capsules. It features ingredients to strengthen hair by targeting the cause, but with the addition of our new Collagen Infusion, you can further protect your hair’s health from the effects of aging.
The Marine Collagen Peptides in Collagen Infusion, along with ingredients such as CoQ10, a blend of citrus flower acids, and amino acids, are said to partially boost skin elasticity on the scalp by replenishing existing collagen peptides. It is This does more than just support the base of the hair follicle. It also strengthens the hair fibers and prevents age-related hair breakage and hair loss. Nutrafol calls Collagen Infusion the first and only collagen product of its kind for hair health.
Traditional Herbs Currently Being Clinically Researched
Herbs traditionally used for hair health are also now being clinically validated. has been introduced. is a branded extract of Ageratum conizoides An extract that is a traditional Indian folk remedy for hair loss.
One open-label, randomized, parallel design pilot study in 20212 Sponsored by Gencor, we investigated the efficacy of Gencor’s topical formulations. A. conizoides Extract on hair growth, quality of life, 5-alpha reductase gene expression, and prostaglandin D2 release in 23 adult men and women with hair loss. A. conizoides Apply the gel topically to the scalp twice daily for 8 weeks. Subjects were randomly assigned to use either the 1% or 0.5% concentration gel formulation.
Subjects participated in hair measurement assessments at baseline and biweekly. Subjects also completed self-report measures, such as the Hair Loss Quality Distress Questionnaire to measure the level of subjective distress about hair loss and a self-assessment questionnaire to assess participants’ subjective perceptions of hair loss. Did. This study includes in vitro Ingredients that measured the effect of A. conizoides 5-α-reductase expression and prostaglandin D2 (PGD2) release in human dermal papilla cells.
48 hours later, A. conizoides It decreased the expression of 5α-reductase and inhibited the release of PGD2. in vitro study. In human trials, both groups showed a decrease in questionnaire scores after 8 weeks. More than 90% of men showed new hair growth. in vitro The component seems to validate the mechanism of action of the ingredients.
Gencor marketing director Maggie McNamara says the hair health market is past the point of consolidation. There’s no shortage of hair health products on the market, but scientific research is changing the game, she says.
“There has been nothing new in this segment for quite some time,” says McNamara. “The next generation of hair care products must be more technical and science-based to better perform for your specific hair needs.”
Consumer Favorites – But Better
Suppliers are also investing in developing new and updated forms of traditional ingredients in this category that boast improved absorbability, improved bioavailability, or flexibility for different product formats. Elyse Lovett said earlier this year, formulators were drawn to ingredients familiar to consumers and were working to improve them. (Lovett was previously Vice President of Marketing for Nutrition21 (Harrison, NY), before launching her own consulting and marketing agency, Lovett Marketing and Advertising Agency LLC.)
Take biotin, for example, which is used repeatedly by leading formulators. “Biotin has been a staple nutrient in supplements for hair, skin and nail benefits,” he said.Unfortunately, the last decade has seen no innovation in the biotin space. . ”
In response, in 2021, Nutrition21 launched Lustriva, a patented Arginine Silicate/Magnesium Biotinate complex. The form of biotin in Lustriva is 40 times more soluble than D-biotin, the form most commonly used in hair health supplements, the company says.
A Recent Randomized, Double-Blind, Placebo-Controlled Clinical Trial3 examined the effects of lastriva on hair thickness and density in 90 women aged 21 to 65 years. These subjects were experiencing thinning hair. This trial was conducted by the contract research agency Nutrasource (Guelph, Canada) on behalf of the study sponsor, his JDS Therapeutics (Harrison, NY). JDS Therapeutics is the parent company of Nutrition21.
Subjects were assessed for hair density and root health via the TrichoScan HD system, a computer-based test method that calculates hair density. For 12 weeks, subjects were randomized to receive 1) 1 capsule daily of high-dose Lustriva containing 146.5 mg arginine silicate and 11.7 mg magnesium biotate, 2) 1 capsule daily of low-dose 146.5 mg arginine silicate They were assigned to take one capsule of Lastrieva daily. and 3.5 mg magnesium biotinate, or 3) placebo.
After three weeks, the high dose group experienced a statistically significant change in the vellus-to-terminal hair ratio that was maintained throughout the study. .
Lovett said Lustriva’s ingredients have GRAS status and offer flexibility in formulation. Lustriva can be easily incorporated into RTD beverages, dry he mixes, gummies, capsules and tablets.
Emergence of postbiotics
Herbal extracts have dominated hair health formulas, but the market is now seeing an influx of probiotics designed to promote hair health and growth. It’s no surprise that some of the enzymes are beneficial to hair health,” said Dr. Muhammad Majid, founder and chairman of materials supplier Sabinsa, Inc. (East Windsor, NJ).
This is also sparking the entry of postbiotics into the hair health market.[Sabinsa’s branded] Lactosporin, secreted by Sabintha’s unique probiotic, Lactospore, has the surprising property of inhibiting 5α-reductase, which contributes to hair growth. Launched in 2019, lactosporin is a patented post-biotic ingredient derived from the purified supernatant of Sabinsa’s patented lactospores. bacillus coagulans MTCC 5856 probiotic strain.
The company is currently investigating the potential of lactosporin for hair health. 1 randomized, open-label study in 2020Four A study conducted and funded by Sabinsa compared the effectiveness of a 2% lactosporin face cream versus benzoyl peroxide solution for mild to moderate acne in 64 men and women between the ages of 18 and 35. . in vitro A component evaluated for the 5α-reductase inhibitory properties of lactosporin. 5α-reductase is an enzyme that breaks down testosterone into dihydrotestosterone, the hormone thought to cause hair loss.
in the in vitro As a component of this study, human dermal papilla cells were incubated overnight in Dulbecco’s modified Eagle’s medium and 10% fetal bovine serum. Cells were then exposed to 50 nm of testosterone administered with or without lactosporin and incubated for an additional 48 hours. Lactosporin was administered at five concentrations ranging from 0.13% to 2%. The resulting supernatants were assessed for 5-alpha dihydrotestosterone levels using an ELISA kit. Analysis revealed that lactosporine inhibited 5-alpha reductase at all concentrations, but the highest inhibition of 17% was achieved at the 0.5% concentration.
Investment in research fuels new products
Hair health products are becoming more personalized with an emphasis on proven ingredients.Supplier investments in clinical trials and clinical trials in vitro Studies have validated specific hair health nutrients, making it easier for brands to earn consumer trust. As consumers show renewed interest in hair health and have a more sophisticated understanding of the role of nutrition in promoting hair growth, hair health nutrition brands are well placed to meet the growing expectations. You will find success with proven hair health formulas that can.
References
- Transparency market research report. “Hair Supplements Market (Types: Single and Multi-ingredient; Properties: Organic and Conventional; Forms: Powders, Gummies and Softgels, Tablets, Capsules, and Liquids; Sales Channels: Hypermarkets/Supermarkets, Specialty Stores, Drugs & Pharma) Stores, and Online Retail) – Global Industry Analysis, Size, Share, Growth, Trends, and Forecasts, 2021-2031.Published online in 2021.
- Clayton P et al. “Ageratum conizoides L. extract inhibits 5α-reductase gene expression and prostaglandin D2 release in human dermal papilla cells and ameliorates symptoms of hair loss in otherwise healthy men and women in an open-label pilot study. increase. ” Journal of Cosmetology & Trichology, roll. No. 7 1 (2021)
- Kalman DS et al. “A randomized, double-blind evaluation of a novel biotin-silicon ingredient complex on healthy female hair and skin.” Journal of Clinical & Experimental Dermatology Research, roll. 12, no. 1 (2021): 551
- Majid M et al. “A new topical application of a postbiotic, lactosporin, in mild to moderate acne: a randomized controlled clinical study to assess its efficacy, tolerability, and safety.” Cosmetics. Published online on September 15, 2020.
